Our science
An insert & forget solution exploiting the untapped potential of the nasal route to reduce patient exposure and improve adherence to treatment.
In collaboration with our team of clinical, academic and industrial partner experts, we have developed a platform of intranasal inserts for sustained release of active substances. This drug delivery platform, allowing local or Nose-To-Brain administration, aims to improve the treatment plan for chronic diseases.
The untapped potential of the intranasal route
The intranasal route allows rapid absorption of drugs through the highly vascularized nasal mucosa while bypassing hepatic first-pass metabolism, thereby improving bioavailability.
This route is used for both local treatments (e.g., allergies, rhinitis) and systemic delivery (analgesics, hormones, vaccines), and is increasingly explored for biomolecules and direct nose-to-brain therapies.
Research focuses on liquid and semi-solid formulations like mucoadhesive systems and nanoparticles hardly compatible with long-term sustained release (retention time of a few weeks maximum).
Dianosic has a unique positioning with a solid polymeric nasal insert delivering constant API doses over extended periods (up to 12 months), easily placed and removed by healthcare professionals.
A proprietary drug-delivery platform built on three pillars
Tailored pharmaceutical form
- Each insert formulation is a unique combination of API and resorbable polymer, designed to deliver a sustained and controlled dose, whether for local, systemic, or nose-to-brain drug delivery..
- The solid insert can incorporate adjustable quantities of API, enabling drug release a long term thanks to an optimized formulation. Direct and prolonged contact with the mucosa helps overcome the rapid clearance limitations associated with nasal sprays, while the biocompatible polymer matrix ensures local tolerance and minimizes mucosal irritation.
Proprietary insert design
- The insert is shaped for tolerability and flexibility. Mesh structure prevents mucus buildup, reducing the risk of local infection. Edge-free design ensures patient comfort at insertion and removal, preserving mucosa integrity over the treatment period.
- The insert’s features allow various positioning in the nasal cavity: in the turbinates region for local and systemic delivery, and in the olfactory region for nose-to-brain delivery.
Minimally invasive procedure
- An ENT specialist places the intranasal insert during a quick, in-office procedure under local anesthesia.
